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Exercise-induced whole-body dehydration does not affect airway responsiveness in athletes but may impair small airway function
Exercise-induced bronchoconstriction (EIB) is the transient narrowing of the airways that occurs during or shortly after strenuous exercise. Loss of water from the airway surface, due to the conditioning of large volumes of air during exercise, is the main physiological stimulus for EIB. We proposed that exercise-induced whole-body dehydration would interfere with hydration of the airways and, consequently, increase the risk and/or severity of EIB. We also investigated the effects of whole-body dehydration on resting lung function
X-ray Observations of Distant Optically Selected Cluster
We have measured fluxes or flux limits for 31 of the 79 cluster candidates in
the Palomar Distant Cluster Survey (PDCS) using archival ROSAT/PSPC pointed
observations. Our X-ray survey reaches a flux limit of erg s cm (0.4 - 2.0 keV), which corresponds to
luminosities of erg s ( = 50 km
s Mpc, = ), if we assume the PDCS estimated
redshifts. Of the 31 cluster candidates, we detect six at a signal-to-noise
greater than three. We estimate that (90% confidence
limits) of these six detections are a result of X-ray emission from objects
unrelated to the PDCS cluster candidates. The net surface density of X-ray
emitting cluster candidates in our survey, clusters
deg, agrees with that of other, X-ray selected, surveys. It is possible,
given the large error on our contamination rate, that we have not detected
X-ray emission from any of our observed PDCS cluster candidates. We find no
statistically significant difference between the X-ray luminosities of PDCS
cluster candidates and those of Abell clusters of similar optical richness.
This suggests that the PDCS contains objects at high redshift similar to the
low redshift clusters in the Abell catalogs. We show that the PDCS cluster
candidates are not bright X-ray sources, the average luminosity of the six
detected candidates is only erg s (0.4-2.0
keV). This finding is in agreement with previous X-ray studies of high
redshift, optically selected, rich clusters of galaxies.Comment: 19 pages, LaTeX with AAS Preprint Macros (v. 4), 3 embedded
postscript figures, 3 Seperate Tables using aj_pt4.sty, Accepted by the
Astronomical Journal for November 199
Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes
This article is made available through the Brunel Open Access Publishing Fund and is distributed by the Creative Commons CC-BY 3.0 license, under which all are free to reuse or distribute the article under the condition that this original publication must be cited.Repeated injury of the airway epithelium caused by hyperpnoea of poorly conditioned air has been proposed as a key factor in the pathogenesis of exercise-induced bronchoconstriction (EIB) in athletes. In animals, the short-acting β2-agonist terbutaline has been shown to reduce dry airflow-induced bronchoconstriction and the associated shedding of airway epithelial cells. Our aim was to test the efficacy of inhaled terbutaline in attenuating hyperpnoea-induced bronchoconstriction and airway epithelial injury in athletes. Twenty-seven athletes with EIB participated in a randomized, double-blind, placebo-controlled, crossover study. Athletes completed an 8-min eucapnic voluntary hyperpnoea (EVH) test with dry air on two separate days 15 min after inhaling 0.5 mg terbutaline or a matching placebo. Forced expiratory volume in 1 s (FEV1) and urinary concentration of the club cell (Clara cell) protein 16 (CC16, a marker of airway epithelial perturbation) were measured before and up to 60 min after EVH. The maximum fall in FEV1 of 17 ± 8% (SD) on placebo was reduced to 8 ± 5% following terbutaline (P < 0.001). Terbutaline gave bronchoprotection (i.e., post-EVH FEV1 fall <10%) to 22 (81%) athletes. EVH caused an increase in urinary excretion of CC16 in both conditions (P < 0.001), and terbutaline significantly reduced this rise (pre- to postchallenge CC16 increase 416 ± 495 pg/μmol creatinine after placebo vs. 315 ± 523 pg/μmol creatinine after terbutaline, P = 0.016). These results suggest that the inhalation of a single therapeutic dose of terbutaline offers significant protection against hyperpnoea-induced bronchoconstriction and attenuates acute airway epithelial perturbation in athletes.World Anti Doping Agenc
Apparent and actual galaxy cluster temperatures
The redshift evolution of the galaxy cluster temperature function is a
powerful probe of cosmology. However, its determination requires the
measurement of redshifts for all clusters in a catalogue, which is likely to
prove challenging for large catalogues expected from XMM--Newton, which may
contain of order 2000 clusters with measurable temperatures distributed around
the sky. In this paper we study the apparent cluster temperature, which can be
obtained without cluster redshifts. We show that the apparent temperature
function itself is of limited use in constraining cosmology, and so concentrate
our focus on studying how apparent temperatures can be combined with other
X-ray information to constrain the redshift. We also briefly study the
circumstances in which non-thermal spectral features can give redshift
information.Comment: 7 pages LaTeX file with 13 figures incorporated (uses mn.sty and
epsf). Minor changes to match MNRAS accepted versio
Emergence of heterogeneity and political organization in information exchange networks
We present a simple model of the emergence of the division of labor and the
development of a system of resource subsidy from an agent-based model of
directed resource production with variable degrees of trust between the agents.
The model has three distinct phases, corresponding to different forms of
societal organization: disconnected (independent agents), homogeneous
cooperative (collective state), and inhomogeneous cooperative (collective state
with a leader). Our results indicate that such levels of organization arise
generically as a collective effect from interacting agent dynamics, and may
have applications in a variety of systems including social insects and
microbial communities.Comment: 10 pages, 6 figure
Binding-incompetent adenovirus facilitates molecular conjugate-mediated gene transfer by the receptor-mediated endocytosis pathway
Molecular conjugate vectors may be constructed that accomplish high efficiency gene transfer by the receptor-mediated endocytosis pathway. In order to mediate escape from lysosomal degradation, we have incorporated adenoviruses into the functional design of the conjugate. In doing so, however, we have introduced an additional ligand, which can bind to receptors on the cell surface, undermining the potential for cell specific targeting. To overcome this, we have treated the adenovirus with a monoclonal anti-fiber antibody, which renders the virus incapable of binding to its receptor. The result is a multi-functional molecular conjugate vector, which has preserved its binding specificity while at the same time being capable of preventing lysosomal degradation of endosome-internalized conjugate-DNA complexes. This finding indicates that adenoviral binding is not a prerequisite for adenoviral-mediated endosome disruption
A Turn-over in the Galaxy Luminosity Function of the Coma Cluster Core?
Our previous study of the faint end (R21.5) of the galaxy luminosity
function (GLF) was based on spectroscopic data in a small region near the Coma
cluster center. In this previous study Adami et al. (1998) suggested, with
moderate statistical significance, that the number of galaxies actually
belonging to the cluster was much smaller than expected. This led us to
increase our spectroscopic sample. Here, we have improved the statistical
significance of the results of the Coma GLF faint end study (R22.5) by
using a sample of 85 redshifts. This includes both new spectroscopic data and a
literature compilation. The relatively small number of faint galaxies belonging
to Coma that was suggested by Adami et al. (1998) and Secker et al. (1998) has
been confirmed with these new observations. We also confirm that the
color-magnitude relation is not well suited for finding the galaxies inside the
Coma cluster core, close to the center at magnitudes fainter than R19. We
show that there is an enhancement in the Coma line of sight of field galaxies
compared to classical field counts. This can be explained by the contribution
of groups and of a distant cluster along the line of sight. The
result is that the Coma GLF appears to turn-over or at least to become flat for
the faint galaxies. We suggest that this is due to environmental effects.Comment: 8 pages, 6 postscript figures, accepted in A&A, new table 1, updated
figure
The utilization of selection after 100-days lactation in forming a high productive Red and White herd
International audienc
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